calcitonin receptor osteoblast

Calcitonin is a 32 amino acid peptide hormone secreted by parafollicular cells (also known as C cells) of the thyroid gland in humans, and in many other animals in the ultimopharyngeal body. We recently demon-strated that the osteoblast-like cell line U2OS expressed both message and protein for the CT receptor. Calcitonin, a hormone of thyroid gland, suppresses the osteoclastic activity. Calcitonin-gene-related peptide (CGRP) is a neuropeptide, which is widely distributed throughout the central and peripheral nervous systems. The peptide hormone calcitonin was discovered more than 40 years ago, as a hypocalcemic hormone secreted from the parathyroid , .Calcitonin is a 32-amino acid peptide with an intramolecular disulfide bridge between cysteine residues at position 1 and 7, and an amidated carboxy-terminal .Calcitonin has been identified in many species, and salmon calcitonin, sharing only 50% … Numerous mechanisms underlying the action of CGRP in osteoblast-associated cells have been suggested for bone … in vitro, at least as determined with immortalized cell lines [18,19]; the presence of the CT receptor has been reported in the murine osteosarcoma cell line UMR-106–06. Only the calcitonin receptor (CTR) expression unambiguously identifies osteoclasts and distinguishes them from macrophage polykaryons. osteoprotegerin (OPG) calcitonin . This study redefines the role of CT in skeletal biology, confirms that S1P acts as an osteoanabolic molecule in vivo and provides evidence for a pharmacologically exploitable crosstalk between osteoclasts and osteoblasts. Granholm S(1), Lundberg P, Lerner UH. It was reported that OPG inhibits osteoclast differentiation in the final stages, induces apoptosis and suppresses the activation of mature osteoclasts. nonselective S1P receptor agonist FTY720 causes increased bone formation in wild-type, but not in S1P 3-deficient mice. J. Xu, M. D. Kauther, J. Hartl, and C. Wedemeyer, “Effects of alpha-calcitonin gene-related peptide on osteoprotegerin and receptor activator of nuclear factor-kappaB ligand expression in MG-63 osteoblast-like cells exposed to polyethylene particles,” Journal of … Author information: (1)Department of Oral Cell Biology, Umeå University, S-901 87 Umeå, Sweden. ... OPG, on the other hand, is a trap receptor created by osteoblasts which competes with RANKL. decoy receptor produced by osteoblasts and stromal cells that binds to and sequesters RANKL ; Osteoclast Inhibition: Osteoclast Inhibition decreases bone resorption; Molecules that inhibit bone resorption . The data are consistent with the receptor in osteoclasts being a calcitonin receptor and that in osteoblasts being an amylin or adrenomedullin receptor. The osteoclasts do not have receptors for parathyroid hormone (PTH). Calcitonin is available in many administrative forms, with low price and safe to use. To identify and quantify osteoclasts, as well as to study their formation in bone and in osteoclastogenic cultures, osteoclast-specific cell markers are required. However, PTH stimulates the osteoblasts to secrete the cytokine called osteoclast-stimulating factor, which is a potent stimulator of the osteoclastic activity. produce an anabolic effect on osteoblasts. interacts directly with the osteoclast via cell-surface receptors; estrogen (via decrease in RANKL) Calcitonin inhibits osteoclast formation in mouse haematopoetic cells independently of transcriptional regulation by receptor activator of NF-{kappa}B and c-Fms.

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