lynparza professional information

Do not donate sperm while taking this medicine and for 3 months after you stop taking this medicine. These medications are not usually taken together. Patients were randomized 2:1 (N=295):. AstraZeneca encourages you to discuss the information on this website, and seek further information about your condition and treatment from your healthcare professional. This information is not individual medical advice and does not substitute for the advice of a health care professional. There is a potential for serious side effects to an unborn child. The information on this website should not take the place of you talking with your doctor or healthcare professional. Foundation Medicine’s pan tumor liquid biopsy test is now FDA-Approved to identify patients with BRCA1, BRCA2 and/or ATM alterations in metastatic castration-resistant prostate cancer who may be appropriate for treatment with LYNPARZA. SOLO-2 Study Design 1. Only you and your healthcare professional can decide if LYNPARZA is right for you. You should confirm the information on the PDR.net site through independent sources and seek other professional guidance in all treatment and diagnosis decisions. In some cases, health care professionals may use the generic name olaparib when referring to the trade drug name Lynparza™.. Drug type: Lynparza ™ is a targeted therapy. The information of 984degree.com is for reference purpose only, and 984degree.com or 98.4 Pharmacy or 98.4 Online Pharmacy is not intended to be a replacement of professional medical advice, diagnosis, or treatment. Please consult a medical professional for information about a specific prescription drug product. The information on this website is not a substitute for medical advice. Lynparza is also available as a 100 mg and 150 mg tablet. Lynparza® (olaparib) – New indication • On May 8, 2020, AstraZeneca announced the FDA approval of Lynparza (olaparib) , in combination with bevacizumab (eg, Avastin®) for the maintenance treatment of adult patients with advanced epithelial ovarian, fallopian tube or primary peritoneal cancer who are in complete or partial Does LYNPARZA Interact with other Medications? If you would like to make a comment or send us feedback on this material, click here. PATIENT MEDICATION INFORMATION LYNPARZA® Olaparib Tablets Read this carefully before you start taking LYNPARZA and each time you get a refill. Lynparza® (Olaparib) For Microsatellite Instability (MSI) results, confirmatory testing using a validated orthogonal method should be performed. Germline BRCA mutation must be confirmed before LYNPARZA Breast Cancer LYNPARZA (olaparib) is indicated as monotherapy for the treatment of adult patients with It is poly (ADP-ribose) polymerase (PARP) inhibitor - (For more detail, see "How this drug works," below.) Always ask a health care professional for complete information about this product and your specific health needs. LYNPARZA is the first and only PARP inhibitor approved in Japan in mCRPC. Men should not father a child while taking this medicine and for 3 months after stopping it. AstraZeneca are not responsible for the content or privacy / legal policies of any third party websites. Important administration information. Lynparza Dear Healthcare Professional Communication . LYNPARZA Approved as Maintenance Treatment After Platinum-Based Chemotherapy for Patients with BRCAm Curatively Unresectable Pancreas Cancer OOTHER ALTHER ALTERATERATIONS & BIOMARKERS IDENTIFIEDTIONS & BIOMARKERS IDENTIFIED ... professional services section for additional information. Lynparza Oral Cap: 50mg Olaparib Oral Tab: 100mg, 150mg. Further information about the evaluation of olaparib’s benefits can be found in olaparib’s EPAR, including in its plain-language summary, available on the European Medicines Agency ... Distribution of a Direct healthcare Professional Communication (DHPC) to prescribers and pharmacists providing clear information on the 2formulations. AstraZeneca provides this link as a service to our site visitors. It is not intended to be a substitute for the exercise of professional judgment. 98.4 Pharmacy suggest to ask the advice of a physician or any qualified health provider with any questions you may have regarding a medical condition. Prostate cancer is the third most common type of cancer in Japan and in 2020, accounted for over 100,000 new cases. Presence of a third-party trademark does not mean that RxSaver has any relationship with that third party or that such third party endorses or sponsors RxSaver. Do not substitute Lynparza capsules (50 mg) with Lynparza tablets (100 mg and 150 mg) on a milligram-to-milligram basis due to differences in the dosing and bioavailability of each formulation. This leaflet is a summary and will not tell you everything about this drug. The approval, granted under priority review, is specifically indicated for patients who progressed after treatment with new forms of hormone therapy, … Find patient medical information for Lynparza oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. The approval, for patients whose cancer is positive for homologous recombination deficiency (HRD), is based on data from the PAOLA … Generic name: Olaparib Lynparza ™ is the trade name for the generic chemotherapy drug olaparib. NAME OF THE MEDICINAL PRODUCT Lynparza 100 mg film-coated tablets Lynparza 150 mg film-coated tablets Please consult a medical professional for information about a specific prescription drug product. Talk to your healthcare professional about your medical condition and treatment and ask if there is any new LYNPARZA tablets 300 mg BID (n=196); Placebo BID (n=99) Patients receiving LYNPARZA and ADT had a 6% incidence of pulmonary … Product Monograph – LYNPARZA® Tablets COPYRIGHT 2018-2019 ASTRAZENECA CANADA INC.Page 6 of 67 PART I: HEALTH PROFESSIONAL INFORMATION 1 INDICATIONendocrine therapy. Thank you for visiting the Lynparza-canada website. Talk to your health care professional or pharmacist for more information. Positive topline data announced from PIII randomised, double-blinded, placebo-controlled, multi-centre POLO trial ((NCT02184195, n=154) in which pts were randomised (3:2) to receive Lynparza (300mg BD) or placebo until the disease progressed. Healthcare Professional Information Leaflet 1 Reference: EU SmPC (SOLO-1) AZ Doc ID: Doc ID-004054052, v.5.0 1. Dear Healthcare Professional Communication . This link will take you to a website not owned by AstraZeneca. SOLO-2 was a randomized, phase 3 study of 295 patients with a gBRCA1 and/or gBRCA2 mutation with platinum-sensitive relapsed ovarian, fallopian tube, or primary peritoneal cancer who received ≥2 prior lines of platinum-containing regimens.. The information on this website should not take the place of you talking with your doctor or healthcare professional. Canadian authorities have approved Lynparza (olaparib) as an oral treatment for people with metastatic castration-resistant prostate cancer (mCRPC) who carry mutations in BRCA or ATM genes, both of which are involved in DNA repair.. If you have any questions about your condition, or would like more information about LYNPARZA, talk to your doctor or pharmacist. Lynparza (olaparib) is an oral treatment developed by AstraZeneca in collaboration with Merck (known as Merck in the U.S. and Canada, but as MSD everywhere else) f or advanced ovarian, pancreatic and certain types of metastatic breast cancer.. Refer to the full prescribing information for Lynparza capsules for specific capsule dosing. For Healthcare Professionals. Olaparib is the first in a class of drugs that inhibit poly(ADP)-ribose polymerase (PARP). CAMBRIDGE, Mass.--(BUSINESS WIRE)-- Foundation Medicine, Inc. today announced that it has received approval from the U.S. Food and Drug … Patients will directly benefit from the most updated product information, which will improve patient safety, side effect management and adherence. Trademarks other than RxSaver’s are the property of their respective owners. Dear Healthcare Professional, AstraZeneca in agreement with the European Medicines Agency and the Health Products Regulatory Authority (HPRA) would like to inform you of the following: Summary Liability pCODR does not assume any legal liability or responsibility for the accuracy, completeness or usefulness of any information, drugs, therapies, treatments, products, processes, or services disclosed. Professional information for Lynparza . LYNPARZA (Olaparib): Risk of medication errors with new pharmaceutical form. Send us feedback. patient or other professional judgment in any decision making process, or as a substitute for professional medical advice. Indications. Lynparza (olaparib) has been approved in Japan as a maintenance treatment for women with advanced ovarian cancer who responded to a first-line chemotherapy regimen containing bevacizumab, AstraZeneca and Merck announced in a press release.. Lynparza (olaparib) is an oral maintenance treatment, approved that the U.S. Food and Drug Administration (FDA) for men with metastatic castration-resistant prostate cancer (mCRPC) who carry mutations in homologous recombination repair (HRR) genes, including BRCA or ATM.. 27th November 2020 . Severe Interactions . Whether you need to cross-check an indication, help a patient understand their condition, or catch up on a recent meeting, you'll find the right information fast, letting you return to your number one priority: helping your patients. Presence of a third-party trademark does not mean that RxSaver has any relationship with that third party or that such third party endorses or sponsors RxSaver. Certain Risk Minimisation Materials on this website are intended for use by healthcare professionals only. Trademarks other than RxSaver’s are the property of their respective owners. This page is intended for Australian patients taking Lynparza tablets. Lynparza ® (olaparib) – New indication • On May 20, 2020, AstraZeneca and Merck announced the FDA approval of Lynparza (olaparib), for the treatment of adult patients with deleterious or suspected deleterious germline or s omatic homologous recombination repair (HRR) gene-mutated metastatic castration-resistant prostate The following information is provided for clinicians and other healthcare professionals. Venous Thromboembolic Events: Including pulmonary embolism, occurred in 7% of patients with metastatic castration-resistant prostate cancer who received LYNPARZA plus androgen deprivation therapy (ADT) compared to 3.1% of patients receiving enzalutamide or abiraterone plus ADT in the PROfound study. TESARO recognizes the importance of optimizing patient care and outcomes by providing people bravely facing cancer with accurate, informative, and relevant product education materials. LYNPARZA is a first-in-class PARP inhibitor and the first targeted treatment to potentially exploit DNA damage response (DDR) pathway deficiencies, such as BRCA mutations, to preferentially kill cancer cells. If you have any questions about your condition, or if you would like more information about LYNPARZA, talk to your doctor or pharmacist. . ... (12.3)]. Continued . Only you and your healthcare provider can decide if LYNPARZA is right for you. Do you wish to continue? .

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