what is adenuric used for

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Preventie en behandeling van hoge urinezuurwaarden bij patiënten die een chemotherapie tegen Adenuric treatment should not be stopped if an attack of gout occurs. endstream endobj 127 0 obj <>/Metadata 9 0 R/Outlines 18 0 R/PageLayout/OneColumn/Pages 124 0 R/StructTreeRoot 39 0 R/Type/Catalog>> endobj 128 0 obj <>/ExtGState<>/Font<>/XObject<>>>/Rotate 0/StructParents 0/Tabs/S/Type/Page>> endobj 129 0 obj <>stream Adenuric® 120 mg tablets is also used … Adenuric is used to treat adults with long-term hyperuricaemia (high levels of uric acid or ‘urate’ in the blood). Your doctor may have prescribed it for another reason. It is generally recommended only for people who cannot take allopurinol. The medicine can only be obtained with a prescription. ADENURIC tabletten bevatten de werkzame stof febuxostat en worden gebruikt voor de behandeling van jicht, een ziekte die in verband wordt gebracht met een teveel aan een chemische stof in het lichaam die urinezuur (uraat) wordt genoemd. h�bbd``b`�$��X��?�`., �#�0� �e ���MHpE �h��- !�$�$��X߁��?&F^ ����r�?c�'� M)J Febuxostat, sold under the brand names Uloric and Adenuric among others, is a medication used long-term to treat gout due to high uric acid levels. When this happens in the joints and causes pain, it is known as ‘gout’. %PDF-1.5 %���� Adenuric Tablet may also be used for purposes not listed in this medication guide. Adenuric is used to treat adults with long-term hyperuricaemia (high levels of uric acid or Nurate' in the blood). The first study, carried out in 1,072 patients, compared three doses of Adenuric (80, 120 and 240 mg once a day) with placebo (a dummy treatment) and allopurinol (another medicine used to treat hyperuricaemia). Possible risks and side effects For the prevention and treatment of hyperuricaemia in patients undergoing chemotherapy, Adenuric has been studied in one main study involving 346 adult patients undergoing chemotherapy for blood cancer. Hyperuricaemia can lead to urate crystals forming and building up in the joints and the kidneys. Adenuric is a substance used for the treatment of gout, to reduce the production of uric acid in the body. The European Commission granted a marketing authorisation valid throughout the European Union for Adenuric on 21 April 2008. The study lasted six months. This medicine is authorised for use in the European Union. Febuxostat is used to treat gout. in the blood). Adenuric is a medicine that contains the active substance febuxostat. It is these crystals that cause the characteristic pain and inflammation of gout.Uric acid is produced by an enzyme in the body called xanthine oxidase. What ADENURIC is and what it is used for 3 2. Uric acid buildup can lead to gout or kidney stones. In some people, the amount of uric acid builds up in the blood and may become too high to remain soluble. Adenuric tablets contain the active ingredient febuxostat, which is a type of medicine called a xanthine oxidase inhibitor. For the treatment of long-term hyperuricaemia, the recommended dose of Adenuric is 80 mg once a day. %%EOF Keeping uric acid levels low by taking Adenuric® once every day stops crystals building up, and over time it reduces symptoms. The active substance in Adenuric, febuxostat, reduces the formation of uric acid. If serum uric acid is > 6 mg/dL (357 µmol/L) after 2-4 weeks, ADENURIC 120 mg once daily may be considered. In some people, the amount of uric acid builds up in the blood and may become too high to remain soluble. This medicine is not addictive. Adenuric is also used to treat and prevent high levels of uric acid in the blood in adults with blood cancers who are on chemotherapy and at risk of tumour lysis syndrome (a complication due to the breakdown of cancer cells causing a sudden rise of uric acid in the blood which can cause damage to the kidneys). Menarini Farma heeft bekend gemaakt dat Adenuric® (febuxostat) volledig wordt vergoed voor jicht patiënten, mits zij niet (meer) behandeld kunnen worden met allopurinol of niet reageren op deze behandeling. This substance contains the active ingredient Febuxostat, which can keep uric acid levels from getting overly high in people with gout. Adenuric Tablet is used for High blood uric acid, Painful joint conditions and other conditions. Febuxostat is a xanthine-oxidase inhibitor which is used to treat gout and to prevent its occurrences. It is available as tablets (80 and 120 mg). Keeping uric acid levels low for long enough can also shrink tophi. This is known as a condition called gout. h�b```�~V�>``��0pt0�����! Ask your doctor if you have any questions about why this medicine has been prescribed for you. When initially started, medications such as NSAIDs are often recommended to prevent gout flares. Keeping uric acid levels sufficiently low for a long period can also shrink tophi. In patients who are on chemotherapy a reduction in uric acid levels is expected to reduce the risk of tumour lysis syndrome. The CHMP concluded that Adenuric was more effective than allopurinol at lowering blood uric acid levels including in patients undergoing chemotherapy , but that it could carry a greater risk of side effects affecting the heart and blood vessels. What ADENURIC is used for. Adenuric is indicated for the treatment of chronic hyperuricaemia in conditions where urate deposition has already occurred (including a history, or presence of, tophus and/or gouty arthritis). This is a summary of the European public assessment report (EPAR) for Adenuric. 1. For the treatment of hyperuricaemia and gout, Adenuric has been studied in two main studies involving a total of 1,834 patients. ADENURIC is verkrijgbaar als tablet van 80 mg of 120 mg. Uw arts schrijft u de sterkte voor die voor u het meest geschikt is. Adenuric is used in patients who already have signs of a build-up of crystals, including gouty arthritis (pain and inflammation in the joints) or tophi (‘stones’, larger deposits of urate crystals that can cause joint and bone damage). 147 0 obj <>/Filter/FlateDecode/ID[<2D311DD9BFB61E49AAFE3862AA76FFB1>]/Index[126 38]/Info 125 0 R/Length 100/Prev 73212/Root 127 0 R/Size 164/Type/XRef/W[1 2 1]>>stream Discuss the Adenuric Consumer Medicine Information (CMI) leaflet with the patient. More detail is available in the summary of product characteristics, 31/07/2019 Adenuric - EMEA/H/C/000777 - II/0051. It contains information that is important to you. 2 1. is also used to treat and prev ent high levels of uric acid in the blood in adults with blood Reasons for updating. Menarini International Operations Luxembourg S.A. (MIOL). What is Adenuric used for? Febuxostat is for use only in people who cannot take another medicine called allopurinol, or when allopurinol has stopped working. Learn about febuxostat and other medication for gout online. ADENURIC tabletten bevatten de werkzame stof febuxostat en worden gebruikt voor de behandeling van jicht, een ziekte die in verband wordt gebracht met een teveel aan een chemische stof in het lichaam die urinezuur (uraat) wordt genoemd. ADENURIC is used in the treatment of long-standing high uric acid levels in the blood. 0 Treatment of chronic hyperuricaemia in conditions where urate deposition has already occurred (including a history, or presence of, tophus and/or gouty arthritis). h��W�n�8�>&Y^D��i lڢ�6yPm5֑ Y���3CɖSi��X 'C���p�pHk��F��+�-raD � �� Hyperuricaemia can lead to urate crystals forming and building up in the joints and the kidneys. ADENURIC is used to prevent gout, but is not used to treat acute attacks of gout (also called flares). The main measure of effectiveness was the number of patients whose final three blood uric acid levels were below 6 mg/dl. What you need to know before using ADENURIC 4 Do not use ADENURIC 5 Warnings and cautions 6 Children […] Adenuric was more effective than allopurinol and placebo in treating hyperuricaemia by reducing blood uric acid levels. Adenuric is indicated for the prevention and treatment of hyperuricaemia in adult patients undergoing chemotherapy for haematologic malignancies at intermediate to high risk of Tumor Lysis Syndrome (TLS). It is taken by mouth. Mercaptopurine (mer-kap-toh-pyoo-reen) — used to treat cancer and immune conditions. Hyperuricaemia can lead to urate crystals forming and building up in the joints and the kidneys. Febuxostat is used to keep uric acid levels from getting to high in people with gout. Adenouric is not recommended for the treatment of asymptomatic hyperuricemia (high uric acid in the blood). Adenuric ® works by reducing uric acid levels. The most commonly reported side effects with Adenuric are gout flare-ups, abnormal liver test results, diarrhoea, nausea (feeling sick), headache, rash and oedema (swelling). Hyperuricaemia can lead to urate crystals forming and building up in the joints and the kidneys. Bij sommige mensen hoopt de hoeveelheid urinezuur zich in het bloed op en kan deze zelfs zo hoog worden dat het urinezuur niet langer oplosbaar is. Ask your doctor if you have any questions about why this medicine has been prescribed for you. ((�ct�����"lف�0��E���`�`�crd�b�c�bZ�����A�3�3��1�.��U@[g2�@�j�W��� [8��>�0�:Hq30J�C� If� You are therefore advised to be selective about which sections or pages you wish to print. The second study compared two doses of Adenuric (80 and 120 mg once a day) with allopurinol over one year in 762 patients. Attacks of gout can still occur during the first few months of treatment, so it is recommended that patients take other medicines to prevent attacks of gout for at least the first six months of treatment with Adenuric. Similar results were seen in the second study after a year. High levels of uric acid in the blood lead to development of crystals which deposit in the joints causing pain, swelling and tenderness. Febuxostat may also be used for purposes not listed in this medication guide. [1-3] Adenuric Met de vergoeding van Adenuric is deze effectieve behandeling voor jicht breder toegankelijk voor patiënten. You can take ADENURIC with antacids. Adenuric is used to treat long-term hyperuricaemia (high levels of uric acid or ‘urate’ in the blood). ADENURIC works sufficiently quickly to allow retesting of the serum uric acid after 2 weeks. You can take ADENURIC with or without food. For selected RADAR reviews, NPS MedicineWise summarises the evidence used in developing our conclusions about a new medicine's efficacy and safety using the GRADE criteria for assessing quality of the evidence. This usually reduces blood uric acid levels within two weeks, but the dose can be increased to 120 mg once a day if blood uric acid levels remain high (above 6 mg per decilitre) after two to four weeks.

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